摘要
目的:运用定量组织速度成像技术结合同步心电图评价心肌梗死后心力衰竭大鼠左心室非同步运动的特点。方法:60只成年雄性SD大鼠,随机分为3组:手术4周组(n=25)、手术8周组(n=25)和假手术组(n=10),其中手术组麻醉后开胸,结扎左冠状动脉前降支;假手术组同样开胸,但不结扎冠状动脉。应用定量组织速度成像技术结合同步心电图,测量各室壁节段收缩期峰值速度达峰时间,计算左心室内各非同步化指标。结果:手术组大鼠心功能指标除左心室内径指数随时间推移逐渐增大外,其余指标均随时间推移逐渐下降(P<0.01),而假手术组大鼠各心功能指标之间随着时间的变化差异不明显(P>0.05)。随着时间推移,手术组大鼠左心室非同步指标逐渐延长(P<0.05)而假手术组大鼠的变化不明显(P>0.05)。结论:定量组织速度成像技术结合同步心电图可准确判断左心室内心肌运动的非同步性。
Objective To evaluate intraventrieular systolic dyssynchrony in rats with post-infarction heart failure by quantitative tissue velocity imaging combining synchronous electrocardio- graph. Methods A total of 60 male SD rats were randomly assigned to 3 groups： a 4 week post- operative group and an 8 week post-operation group （ each n = 25, with anterior descending branch of the left coronary artery ligated） , and a sham operation group （n = 10, with thoracotomy and open pericardium, but no ligation of the artery）. The time to peak systolic velocity of regional myocardial in the rats was measured and the index of the left intraventricular dyssynehrony was calculated. Results All indexes of the heart function became lower as the heart failure worsened except the left ventricle index in the post-operative groups. All indexes of the dyssynchrony got longer in the postoperative groups （P 〈 0.05 ）, while the changes in the sham operation group were not significantly different （P 〉 0.05）. Conclusion Quantitative tissue velocity imaging combining synchronous electrocardiograph can analyse the intraventrieular systolic dyssynehrony accurately.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2011年第4期340-345,共6页
Journal of Central South University ：Medical Science
基金
中南大学研究生创新课题~~
关键词
定量组织速度成像
心功能
心力衰竭
非同步化
quantitative tissue velocity imaging
heart function
heart failure
dyssynchrony
