摘要
目的调查总结消化系癌的贫血发生情况。方法回顾性收集2000年1月至2009年6月在北京协和医院住院治疗且明确诊断的消化系癌10218例，其中食管癌1118例，胃癌2418例，十二指肠癌134例，小肠癌85例，肝细胞癌1508例，胆管癌546例，胰腺癌1242例，结肠癌1582例．直肠癌1585例。对其贫血发生情况进行分析。结果按照中国贫血标准（血红蛋白小于120g／L）．接受调查的患者中消化系癌贫血发生率为27．5％（2813／10218），不同肿瘤贫血发生率由高至低依次为小肠癌（64．7％）、十二指肠癌（60．5％）、结肠癌（42．6％）、胆管癌（36．6％）、胃癌（33．3％）、胰腺癌（22．6％）、直肠癌（20．4％）、肝细胞癌（18．7％）和食管癌（10．0％）。在胃癌、胆管癌、胰腺癌、结肠癌和直肠癌中，贫血以高龄患者多见；在小肠癌和胆管癌，贫血以男性患者多见，但在肝细胞癌和胰腺癌中则以女性患者多见（P〈0．05）。结论消化系癌易发生贫血，其中以十二指肠癌和小肠癌发生率最高，胃癌和结肠癌次之．食管癌贫血发生率最低。在某些消化系癌中，贫血发生可能与年龄和性别有关。
Objective To study the prevalence of tumor related anemia in patients with cancer in the digestive system. Methods A total of of 10 218 inpatients were diagnosed with cancer in the digestive system at the Peking Union Hospital from Janary 2000 to June 2009, which included esophageal cancer（n=1118）, gastric cancer（n=2418）, carcinoma of duodenum（n=134）, carcinoma of small intestine （ n =85 ）, hepatocellular cancer （ n= 1508 ）, cholangiocarcinoma （n=546）, pancreatic cancer （n=1242）, colon cancer （n=1582）, and rectal cancer （n=1585）. Patients with hemolytic anemia or hepatorenal dysfunction were excluded. Data pertaining to sex, age and hemoglobin were obtained by chart review. Results According to the China criteria of anemia, the overall anemia rate was 27.5% （2813/10 218）. The prevalence of anemia was 64.7% for small bowel cancer, 60.5% for duodenal cancer, 42.6% for colon cancer, 36.6% for cholaugiocarcinoma, 33.3% for gastric cancer, 22.6% for pancreatic cancer, 20.4% for rectal cancer, 18.7% for hepatocellular cancer, and 10.0% for esophageal cancer. Anemia was more common in older patients in those with gastric cancer, cholangiocarcinoma, pancreatic cancer, colon cancer and rectal cancer. There were more male anemic patients in those with cancer in the small intestine or cholangiocareinoma. However, females were more commonly seen in those with hepatocellular cancer or pancreatic cancer. Conclusions Anemia is common in patients with cancer in the digestive system. The prevalence of anemia is higher in patients with cancer in the duodenum carcinoma or small intestine, followed by colon cancer and gastric cancer, and then esophageal cancer. Anemia may be associated with age or gender in some types of cancer in the digestive system.
出处
《中华胃肠外科杂志》
CAS
北大核心
2011年第5期340-342,共3页
Chinese Journal of Gastrointestinal Surgery
基金
卫生部国家科技支撑计划资助项目（2008BA158802）
关键词
消化系统肿瘤
贫血
血红蛋白
性别
年龄
Digestive system neoplasms
Anemia
Hemoglobin
Gender
Age
