摘要
用昆明种性成熟雌性小鼠,以10mg/m^3及100mg/m^3浓度CS_2吸入染毒,每日2小时,每周6天,染毒3周(相当3～4个动情周期)后给雌小鼠腹腔注射孕马血清及HCG,令超数排卵,并与未经染毒雄性小鼠交配。后处死小鼠,检查受精卵并制备染色体标本。结果,两个染毒组,发育异常卵出现率显著高于对照组,雌原核染色体畸变的受精卵出现率也显著高于对照组。
Kunming adult female mice were exposed to CS2 at concentrations of O, 10 and 100mg/m3 for 2 hours/day, 6 days/week for 3 weeks ( about 3-4 estrous Cycles) . After exposure, the mice were injected intraperitoneally with PMSG and HCG and then were mated with anexposed male mice. After mating, mice were sacrificed. The fertilized ova were examined and chromosomal specimens were prepared. The results indicated that the incidence of maldevelopmental ova of the two exposed groups was higher than that of the control group ( P<0.05 ) , and the incidence of fertilized ova with female pronucleus chromosomal aberration was higher than that of the control group also ( P<0.005 ) .
出处
《卫生毒理学杂志》
CSCD
1990年第3期139-141,共3页
Journal of Health Toxicology
关键词
二硫化碳
受精卵
发育
染色体畸变
Carbon disulphide
Development of fertilized ova
Chromosome aberration
