摘要
目的:研究新疆软紫草多糖(ARPS)对环磷酰胺(CTX)致小鼠免疫功能低下的影响。方法:采用腹腔注射CTX制造小鼠免疫损伤模型,同时应用软紫草多糖100(低)、200(中)、300(高)mg·kg-1 3个剂量给小鼠连续灌胃7 d,观察其对小鼠胸腺指数、脾脏指数、巨噬细胞吞噬指数、血清溶血素水平和淋巴细胞增殖率等指标的影响。结果:ARPS可提高免疫低下小鼠的脏器指数、吞噬指数和血清溶血素水平,可以改善免疫抑制小鼠低下的脾淋巴细胞增殖反应,且以ARPS 200 mg·kg-1剂量组作用较为显著。结论:ARPS对环磷酰胺致免疫功能低下小鼠具有一定免疫增强作用。
OBJECTIVE To investigate the preventive effect of polysaccharide from Arnebia euchroma （Royle） Johnst. （ARPS） in imnmno-suppressed mice induced by cyclophosphamide（CTX）. METHODS The immuno suppressed mice were induced with CTX by ip. Meanwhile, mice were treated with three doses of ARPS at 100, 200, 300 mg·kg-1 by ig for 7 days except in the normal and model groups. The effects of ARPS on thymus index, spleen index, phagocytosis percentage of macrophage, quantitative hemolysis of cock red blood cells and proliferative rate of lymphocytes were observed. RESULTS ARPS could increase indexes of thymus and spleen, the rate of clearance index, quantitative hemolysis of cock red blood cells and enhance the proliferation of splenic lymphocytes. ARPS at 200 mg·kg-1 could significantly increase these indexes. CONCLUSION ARPS significantly improves non-specific and specific immunologic functions of immunosuppressed mice.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第10期829-832,共4页
Chinese Journal of Hospital Pharmacy
基金
石河子大学自然科学与技术创新重点项目(编号:ZRKX2009ZD01-2)
兵团医药卫生专项(编号:2007GG23)
关键词
软紫草多糖
环磷酰胺
免疫作用
Arnebia euchroma （Royle） Johns polysaccharide
cyclophosphamide
immunity
