摘要
目的:观察不同周龄自发性高血压大鼠(SHR)动态血压变化及阻力血管形态。方法:分别选用16周及40周龄的SHR模型,使用遥感监测技术观察清醒、无拘束SHR的动态血压变化,分析不同周龄SHR的血压昼夜变化及变异度,比较不同周龄SHR阻力血管的形态学变化。结果:40周SHR较16周SHR 24 h血压均值高,但无显著差异;16周SHR夜间血压下降率较40周明显升高(P<0.05);40周SHR血压变异系数较16周SHR明显增大。肠系膜动脉(阻力血管)中膜面积/管腔面积比值随着周龄的增加而增加,5周、16周与40周相比有显著差异(P<0.05)。结论:40周SHR动态观察24 h血压变异度较16周SHR大,且随着周龄的增加,阻力血管(肠系膜动脉)的中膜面积/管腔面积增加。
AIM：To observe the changes of ambulatory blood pressure and morphology of resistance vessel in spontaneously hypertensive rats（SHR）at different weeks of ages.METHODS：SHR at the ages of 16-week and 40- week were used.The blood pressure（BP）was monitored by radiotelemetric technique（RTT）.The data of BP,diurnal variation and the variability were analyzed.RESULTS：The results showed that the falling rate of BP at night in 16-week group was larger than that in 40-week group（P〈0.05）.The BP variability in 40-week group was higher than that in 16-week group.Tunica media area/lumen area ratio of arteria mesenterica was increased with aging（P0.05）.CONCLUSION： The variability of 24-hour blood pressure in 40-week-old SHR is higher than that in 16-week-old SHR.Along with the increase in ages,tunica media vasorum area/lumen area in resistance blood vessel（arteria mesenterica） increases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第4期653-657,共5页
Chinese Journal of Pathophysiology
基金
山西省卫生厅科技攻关基金资助项目(No.200818)
关键词
自发性高血压大鼠
动态血压
高血压
Spontaneous hypertensive rat
Ambulatory blood pressure
Hypertension
