摘要
目的 探讨肥胖及其不同测量指标与微量白蛋白尿（MAU）在普通社区人群中的关系.方法 北京地区参加体检的2080例经知情同意的研究对象（男810例,女1270例）,年龄（50.9±13.1）岁,测量身高、体重、腰围、臀围,并计算其BMI、腰臀比（WHR）,化验尿白蛋白/肌酐比值（ACR）,其结果在30～300 mg/g范围内为MAU,根据ACR结果将测试对象分为无蛋白尿组（NAU组）及MAU组.分析不同肥胖指标（BMI、腰围、WHR）与MAU之间的关系.结果 2080例受试者中,BMI（r=0.1276,P＜0.01）、腰围（r=0.0840,P＜0.01）与ACR呈正相关,WHR与ACR无相关性（P＞0.05）.同时显示,BMI≥28 kg/m2（OR=2.02）、腰围≥85 cm（男）或≥80 cm（女）（OR=1.69）在NAU组与MAU组的例数百分比差异有统计学意义（P＜0.05）.BMI在24～＜28 kg/m2、WHR≥0.90（男）或≥0.85（女）在NAU组与MAU组的例数百分比差异无统计学意义（P≥0.05）.Logistic回归分析显示,BMI（OR=1.06）是MAU的危险因素,独立于年龄（OR=1.01）、性别（OR=1.42）、收缩压（OR=1.01）、TC（OR=1.93）、HDL-C（OR=0.54）等因素存在.结论 北京部分社区人群中肥胖是MAU的～个独立危险因素,其中不同的肥胖测量指标与MAU的相关性不尽相同.
Objective To investigate the correlation between microalbuminuria （MAU） and obesity and its indexes, including BMI, waist circumference（WC）, and waist-to-hip ratio（WHR） , among partial community population in Beijing. Methods A total of 2080 subjects who took physical examination in Beijing, including 810 men and 1270 women with a mean age of（50. 9 ± 13. 1 ）years, were enrolled. The informed consent has been achieved from each patients. BMI and WHR were calculated based on collected data of height, weight, WC, and hipline. Urine albumin-creatinine ratio（ACR） within the range of 30-300mg/g was classified as MAU. The subjects were divided into normal albuminuria （ NAU ） group and MAU group. The correlations between MAU and different obesity indexes including BMI, WC and WHR, were analyzed. Results Among the 2080 subjects, there was a positive correlation between BMI （r = 0. 1276,P〈0.01） and ACR, and WC （r = 0.0840, P 〈0.01） and ACR. WHR and ACR was irrelevant （ P 〉 0. 05 ）. In univariate analysis, there was significant difference in BMI ≥ 28 kg/m2 （ OR = 2. 02 ） and WC ≥85 cm （male） or≥80 cm （female） （OR = 1.69 ） between NAU group and MAU group （P 〈 0. 05 ）.There was no significant difference in BMI 24-〈 28 kg/m2, and WHR ≥0. 90 （male） or ≥0. 85 （female）between NAU group and MAU group（ P≥0. 05 ）. Multivariate logistic regression analysis revealed that BMI （ OR = 1.06） was an isolated independent risk factor of MAU from age （ OR = 1.01 ）, female （ OR = 1.42）,systolic blood pressure （OR=1.01）, TC （OR=1.93） and HDL-C （OR=0.54）. Conclusions Obesity is an independent risk factor of MAU among partial community population in Beijing. The correlation between different obesity indexes and MAU also differs.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2011年第5期388-392,共5页
Chinese Journal of Internal Medicine
基金
基金项目：首都医学发展科研基金（2009-2038）
