摘要
目的检测成人难治性及非难治性哮喘患者血清骨桥蛋白(OPN)与转化生长因子β1(TGFβ1)水平,探讨OPN和TGFβ1水平与哮喘治疗效果的相关性,以及难治性哮喘患者血清中OPN和TGFβ1表达的意义。方法采用ELISA方法检测29例难治性哮喘成人患者、20例非难治性哮喘成人患者及20例健康成人的血清OPN和TGFβ1水平。结果难治性哮喘患者血清OPN水平明显高于非难治性哮喘患者及健康人,差异有统计学意义(P<0.05);难治性哮喘患者血清TGFβ1水平明显低于非难治性哮喘患者及健康人,差异有统计学意义(P<0.05);非难治性哮喘患者血清OPN水平与健康人差异无统计学意义,非难治性哮喘患者血清TGFβ1水平低于健康人,差异有统计学意义(P<0.05)。难治性哮喘患者及非难治性哮喘患者的OPN与TGFβ1水平呈负相关(P<0.05)。结论 OPN和TGFβ1参与了难治性哮喘的发病,其水平对于难治性支气管哮喘的早期诊断有一定意义。
Objective To detect serum levels of OPN and TGFβ1 in adult with difficult-to-treat asthma and to investigate their roles in difficult-to-treat asthma.Methods Serum levels of OPN,TGFβ1 were detected by ELAISA in 29 asthmatic adults with difficult-to-treat and 20 asthmatic adults without difficult-to-treat,20 healthy adults served as control group.Results Compared with the without difficult-to-treat asthma group and control group,serum OPN levels were significantly higher（P〈0.05）,but serum TGFβ1 levels were significantly lower in difficult-to-treat asthma（P〈0.05）.Serum OPN levels were negatively correlated with serum TGFβ1 level in asthma.Conclusion There might be an imbalance in serum OPN,TGFβ1 levels in adults with difficult-to-treat asthma.The abnormal serum levels of OPN and TGFβ1 may be useful in the diagnosis and severity evaluation of difficult-to-treat asthma.
出处
《安徽医科大学学报》
CAS
北大核心
2011年第5期473-475,共3页
Acta Universitatis Medicinalis Anhui
