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国产替罗非班在急性心肌梗死介入治疗后无复流的疗效观察 被引量:1

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摘要 目的观察急性心肌梗死介入治疗后无复流的发生,探讨血小板糖蛋白GPⅡb/Ⅲa受体拮抗剂盐酸替罗非班对ST段抬高型AMI(STEAMI)患者PCI中无复流现象的疗效及安全性。方法对18例急性心肌梗死患者行介入治疗后发生无复流的患者使用国产替罗非班冠状动脉内注入治疗。观察应用后半小时冠状动脉血流情况、心电图及应用24h后,停用1周后心电图,临床出血反应等情况。结果应用国产替罗非班治疗后冠状动脉血流13例由TIMI 0~1级恢复至3级,5例恢复至2级。心电图示抬高的ST段回落,0.5h、24h、1周后相关冠状动脉血管分布范围心电图无再抬高。应用过程中3例患者穿刺部位渗血,1例齿龈渗血,均在减少应用剂量和压迫止血后缓解。无脑出血等严重不良反应。结论国产替罗非班在急性心肌梗死介入治疗后无复流时应用可明显改善冠状动脉血流,安全性好。
出处 《中国医药指南》 2011年第13期75-76,共2页 Guide of China Medicine
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  • 1Ito H,Taniyama Y,Iwakura K,et al.Intravenous nicrandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction[J].J Am Cell Cardiol,1999,33(3):654-660.
  • 2Kenner MD,Zajac EJ,Kondos GT,et al.Ability of the no refow phenomenon during an acute myocardial infarction to predict left ventricular dyfunction at one month follow up[J].Am J Cardiol,1995,76(12):861-868.
  • 3高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量:5257
  • 4李胜利,党瑜华,黄振文.替罗非班治疗急性冠脉综合征临床观察[J].郑州大学学报(医学版),2004,39(3):490-492. 被引量:23
  • 5陈珏 乔树宾等.替罗非班在冠脉支架植入术中应用安全性及耐受性评价[J].中华实用医学杂志,2004,18:4-4.

二级参考文献8

  • 1Anonymous. Effects of platelet glycoprotein Ⅱ b/Ⅲ a blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. Circulation, 1997,96 ( 5 ): 1 445
  • 2CAPTURE investigators. Randomized placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina:the CAPTURE study. Lancet, 1997,349(9 118) :1 429
  • 3Anonymous. Randomized placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary glycoprotein Ⅱ b/Ⅲa blockade. Lancet,1998,352(9 122) :87
  • 4Anonymous. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. the platelet receptor Inhibition in ischemic syndrome management(PRISM) investigators. N Engl J Med,1998,338(21) :1 498
  • 5Anonymous. Inhibition of platelet glycoprotein Ⅱ b/Ⅲ a with eptifibatide in patients with ac ute coronary syndromes: the PuRSuIT trial investigators platelet glycoprotein Ⅱ b/Ⅲ a in unstable angina: receptor suppression using integrillin therapy. N En
  • 6Anonymous. International, randomized, controlled trial of lamifiban ( a platelet glycoprotein Ⅱ b/Ⅲ a inhibitor), heparin, or both in unstable angina: the PARAGON investigators platelet glycoprotein Ⅱ b/Ⅲ a antagonism for the reduction of acute corona
  • 7O′Neill WW,Serruys P,Knudtson M, et al. Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. N Engl J Med,2000,342(18) :1 316
  • 8Bra unwald E, Antman E, Beasley J, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. J Am Coll Cardiol,2000,36 ( 3 ) :970

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