摘要
目的探讨氯吡格雷与阿司匹林联合应用治疗不稳定性心绞痛(UA)的临床疗效和安全性。方法146例UA患者随机分成治疗组(74例)和对照组(72例),2组患者均常规应用抗心绞痛药物治疗(包括阿司匹林、低分子肝素、硝酸酯类及β受体阻滞剂等)。治疗组在常规治疗的同时,首次给负荷剂量的氯吡格雷300 mg口服,继之75 mg/d口服。治疗期间记录2组心绞痛的发作情况、含服硝酸甘油次数、12导联心电图变化及药物主要不良反应(出血)。2组治疗4周后进行疗效比较。结果治疗组62例UA患者的症状和心电图有明显改善,总有效率83.8%,对照组47例UA患者的症状和心电图有明显改善,总有效率65.3%,2组总有效率比较有显著性差异。2组均未见严重出血反应。结论氯吡格雷与阿司匹林联合应用治疗UA疗效满意,优于单独应用阿司匹林的常规治疗效果。
Objective To investigate the effect and safety of the combined therapy of clopidogrel and aspirin in patients with unstable angina pectoris （UA）. Methods 146 patients with UA, al undergoing standard treatment （ with aspirin, low molecular heparin, nitrate and [3 receptor blocker）, were randomly divided into a test group （n = 74 ） and a control group （ n = 72）. The test group were administered a course of additional clopidogrel （ priming dose 300 mg, daily dose 75 mg）. The results were compared four weeks later. Results Evaluation of symptomatic relief and improvement of ST depression on ECG justified that the rate of effectiveness was 86.8% and 65.3% for the test group and the control group respectively. The difference was significant （P 〈 0.05 ）. No severe adverse effects were found in either group. Conclusion The treatment with combined elopidogrel and aspirin is superior to the conventional therapy containing aspirin alone for unstable angina pectoris.
出处
《徐州医学院学报》
CAS
2008年第9期590-592,共3页
Acta Academiae Medicinae Xuzhou
