摘要
作者研究观察了亚硝酸钠和 Ｎ－ 甲基苄胺的遗传毒性作用。结果表明，亚硝酸钠和 Ｎ－ 甲基苄胺不产生急性遗传毒性（ Ｐ＞ ０ ．５） ，但具有中长期遗传毒性。长期接触可诱发大鼠胃窦及食道上皮的增生性病变，使胸腺指数降低，骨髓细胞 Ｍ Ｎ‰升高。
The genotoxicity of sodium nitrite and N methylbenzylamine were detected. The results showed that sodium nitrite and N methybenzylamine did not induce acute genotoxicity(P>0.5),but had a middle and long term genotoxicity. Exposed for long term, the gastric antrum and exophagus in the rats showed different levels hyperplastic change; and the per mil rate of micronuclei of marrow cells increased; the thymus gland indexes lowered.
出处
《癌变·畸变·突变》
CAS
CSCD
1999年第5期227-229,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
