摘要
目的:探讨钩藤碱对膀胱过度活动(overactive bladder,OAB)的治疗作用。方法:将60只SD大鼠随机分为4组,每组15只。假手术组不予任何处理;OAB组:给予手术处理,制备大鼠OAB模型;钩藤碱干预组:对OAB大鼠给予腹腔注射钩藤碱(5 ml.kg-1);生理盐水干预组:对OAB大鼠给予腹腔注射生理盐水(5 ml.kg-1)。各组分别进行尿流动力学检测和逼尿肌肌条的电生理学指标测定。结果:与OAB组和生理盐水干预组对比,钩藤碱干预组膀胱最大容量、膀胱充盈压和漏尿点压减小,收缩频率和动力指数(MI)降低,差异均有统计学意义(P<0.01)。结论:钩藤碱对OAB有治疗作用。
Objective： To investigate the effect of Rhynchophylline on treating overactive bladder （OAB）. Meth- ods ： Sixty SD rats were randomly divided into four groups ： sham operation group, OAB model group （ rats were re- ceived surgical treatment to establish OAB model）, Rhynchophylline-intervening group [ the OAB rats were given intraperitoneal injection of Rhynchophylline （5 ml · kg^-1 ） ], saline-treatment group [ OAB rats were given intrap- eritoneal injection of saline （5 ml·kg^-1） ]. Section of urodynamic testing and electrophysiological indicators of de- trusor were mesared. Results： Compared with the OAB model group and the saline-treatment group, the maximum capacity of the bladder, bladder filling pressure, leak point pressure, contraction frequency and motility index （MI） in the Rhynchophylline- intervening group were significantly reduced （ P 〈 0.05 ）. Conclusion： Rhyncho- phylline plays an important role in the treatment of OAB.
出处
《东南大学学报（医学版）》
CAS
2011年第2期328-331,共4页
Journal of Southeast University(Medical Science Edition)
基金
辽宁省教育厅科研项目计划(L2010296)
关键词
膀胱过度活动
钩藤碱
逼尿肌肌条
overactive bladder
Rhynchophylline
detrusor muscle
