摘要
以3,6-二氯哒嗪为原料,与10%的氢氧化钠溶液在110℃下反应生成3-羟基-6-氯哒嗪,经钯碳催化脱氯得到3-羟基哒嗪,再与三氯氧磷在80℃下回流,制得目标化合物3-氯哒嗪,总收率54.1%,其结构经1H NMR分析确认。
The 3-hydroxy-6-chloropyridazine was prepared using 3,6-dichloropyridazine as starting material with sodium hydroxide at 110 ℃.The 3-hydroxypyridazine was synthesized via palladium on activated carbon dechlorination.Reaction of 3-hydroxypyridazine with phosphorus oxychloride at 80 ℃ gave the target compound 3-chloropyridazine,and the total yield was 54.1%.Its structure was confirmed by 1H NMR analysis.
出处
《应用化工》
CAS
CSCD
2011年第3期547-549,共3页
Applied Chemical Industry
基金
西安市科技创新基金项目(CX08063)
关键词
3-氯哒嗪
合成
收率
3-chloropyridazine
synthesis
yield
