摘要
通过3-氯-6-溴甲基哒嗪与各种取代的苯酚在K2CO3/DMF体系中反应,合成了一系列3-取代苯氧甲基-6-氯哒嗪化合物.它们的结构均经1HNMR,IR和元素分析确证.在浓度为100μg?mL-1时,初步的生物活性测试结果表明,所合成的化合物对油菜和稗草均有一定的抑制作用.并讨论了其结构与除草活性的关系.
A series of 3-（substituted phenoxymethyl）-6-chloropyridazine derivatives were synthesized as herbicide candidates by the treatment of different phenols with 3-chloro-6-methylpyridazine in DMF catalyzed by K2CO3. The new compounds were identified by 1H NMR, IR spectra and elemental analyses. Preliminary bioassay showed that all of them had herbicidal activity against Brassica napus and Echinochloa crusgalli at 100 μg·mL^-1. The structure-activity relationship was discussed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2007年第5期593-596,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学青年基金(No.20302004)资助项目.
关键词
3-取代苯氧甲基-6-氯哒嗪
合成
除草活性
构效关系
3-（substituted phenoxymethyl）-6-chloropyridazine
synthesis
herbicidal activity
structure-activity relationship
