摘要
3,6-二氯哒嗪和氯气反应生成3,4,6-三氯哒嗪,再用甲醇和氨气氨化合成3,6-二氯-4-氨基哒嗪,最后经催化脱氯制得目标化合物4-氨基哒嗪,摩尔总收率达48.2%。通过熔点测定、1H NMR及质谱确认产品。
The starting material 3,6-dichloropyridazine reacts with chlorine to produce 3,4,6-trichloropyridazine.And then followed with methanol and ammonia to synthesize 3,6-dichloro-4-aminopyridazine,which via catalytic dechlorination reaction achieves object compound 4-amino pyridazine and gave a 48.2% overall molar yield.Its structure was analyzed and characterized through melting point testing,1H NMR and mass spectrometry.
出处
《应用化工》
CAS
CSCD
2013年第8期1489-1491,共3页
Applied Chemical Industry
基金
西安市科技创新基金(CX08063)
