摘要
目的:研究美沙酮维持治疗门诊多次脱毒失败病人脱失的危险因素,为有针对性地进行干预,降低美沙酮维持门诊治疗点的脱失率,有效防止复吸提供依据。方法:使用海洛因依赖相关因素调查表对四川省成都及乐山地区两个美沙酮维持治疗门诊两次以上脱毒失败的海洛因依赖者进行调查,保持每两周随访一次6,个月后将尚在维持治疗及脱失的人员分为两组,用Cox生存回归方法分析治疗脱失危险因素。结果:多因素Cox回归分析显示:戒药次数越多,最大使用量越大者脱失率越高。结论:既往戒药次数多,曾经使用毒品量较大的成瘾者容易脱失,建议门诊事先对病人进行评估,对具有危险脱失因素者进行针对性地干预,坚持随访,降低脱失率,防止复吸。
Objective： To study the risk factors for drop-out of methadone maintenance treatment（MMT） for conducting intervention in a targeted manner,improving retention rate of MMT and preventing drug relapse effectively.Methods：An investigation was conducted among MMT outpatients who failed in drug detoxification more than twice with a questionnaire.All the MMT outpatients on investigation were enrolled from two MMT clinics in Chengdu and Leshan.Follow-up visits were done once every other week.Six months later,the patients were divided into two groups,one group consisted of those who maintained in MMT treatment and one group drop-out patients.Analysis of the risk factors for drop-out with Cox survival regression was made.Results：Multi-factor Cox survival regression result showed：the more times for drug detoxification and larger drug dosing,the higher the rate of drop-out.Conclusion：Those who have done drug detoxification more in the past and have used large dose of abused drugs are easy to drop-out of MMT treatment.We suggest that MMT clinics should evaluate patients in advance before treatment,intervene potential risk factors during treatment among the patients and keep on follow-up visits so as to cut down the rate for drop-out and prevent drug relapse.
出处
《中国药物依赖性杂志》
CAS
CSCD
2011年第2期145-148,共4页
Chinese Journal of Drug Dependence
关键词
美沙酮维持治疗
药物滥用
脱失
methadone maintenance treatment
drug abuse
drop-out
