摘要
目的：探讨肝脏瞬时弹性探测仪（Fibroscan,FS）对慢性乙型肝炎肝脏纤维化的诊断价值。方法：对88例慢性乙型肝炎患者行FS检查,记录所检测到的肝硬度值。所有受试者均于同期行肝穿刺活检。以肝活检病理结果为金标准绘制FS工作特征曲线,计算曲线下面积（AUC）,评价其对慢性乙型肝炎肝脏纤维化的诊断价值。结果：肝硬度检测值与肝脏病理分期呈正相关（r=0.747,P〈0.01）。FS对显著纤维化（S2~S4期）、严重纤维化（S3~S4期）和早期肝硬化（S4期）的AUC值分别为0.857、0.934和0.948,以灵敏度和特异度之和的最大值选定的最优cut-off值分别为7.25、9.25和12.4kPa。结论：FS可以较准确地估计慢性乙型肝炎患者纤维化程度,对乙型肝炎的诊断和治疗有指导意义。
Objective：To investigate the diagnostic value of Fibroscan for liver fibrosis in patients with chronic hepatitis B （CHB）. Methods：Eighty-eight patients with CHB were enrolled in this study. All of the patients underwent liver biopsy and liver stiffness measurement（LSM）by Fibroscan. With liver biopsy as the gold standard, ROC curves were delineated for different endpoints. The area under the ROC curves （AUC） was used to evaluate the diagnostic value for liver fibrosis in patients with CHB. Results：There was a positive correlation between the AUCs of Fibroscan and liver pathological stage （r =0.747,P 0.01）. The AUC values of fibroscan were 0.857, 0.934 and 0.948 for the significant fibrosis （S2-S4）, extensive fibrosis （S3-S4） and early cirrhosis （S4）. The optimal LSM cut-off values were 7.25, 9.25 and 12.4 kPa by maximizing the sum D of sensitivity and specificity. Conclusion：Fibroscan is a reasonable noninvasive tool for the assessment of liver fibrosis, which is of great importance in the diagnosis and treatment for CHB.
出处
《天津医药》
CAS
北大核心
2011年第3期236-238,共3页
Tianjin Medical Journal
