摘要
目的分析慢性肝炎患者肝纤维化血清学指标与肝穿病理分期的相关性。方法回顾性统计分析2010年6月～2012年6月在本院确诊的慢性肝炎患者74例肝穿刺标本和血清学纤维化指标PⅢP、Ⅳ-C、HA、LN的资料。结果 74例患者血清PⅢP、Ⅳ-C、HA、LN与病理分期、分级呈良好的正相关,且与病理分期的正相关关系较分级明显。慢性乙肝患者肝组织学纤维化不同分期、不同分级间与HA、LN、PⅢP、Ⅳ-C四项血清纤维化指标关系秩和检验结果显示,随着肝纤维化程度加重,其值有逐渐升高的趋向,各项指标差异均有统计学意义(P<0.05或P<0.01)。结论四项肝纤维化检测指标,能较好地反映肝纤维化的发展,预测肝硬化,结合肝穿刺等其他检测,可提高诊断的准确性。
Objective To analyze the correlation of serological markers of liver fibrosis and liver biopsy stage in patients with chronic liver disease. Methods The liver puncture specimens and detection of serological fibrosis markers P Ⅲ P, Ⅳ-C, HA, LN level data of 74 cases of patients with chronic hepatitis from June 2010 to June 2012 in our hospital were analyzed retrospectively. Results PⅢ P, IV-C, HA, LN and pathological stage, grade of 74 patients showed a good positive correlation, and positive correlation with pathological stage was more obvious than grading. The rank-sum test results between different stages, grading of chronic hepatitis B patients with liver histological fibrosis and HA, LN, P Ⅲ P, Ⅳ-C four serum fibrosis markers showed that, with the severity of hepatic fibrosis, the value had the trend of gradually increase, the differences of these indicators were all statistically significant （P 0.05 or P 0.01）. Conclusion Four liver fibrosis indicators detection can better reflect the development of liver fibrosis predict cirrhosis combined transhepatic and other detection can improve the accuracy of diagnosis.
出处
《中国当代医药》
2013年第1期97-98,共2页
China Modern Medicine
关键词
血清学指标
肝穿病理分期
慢性肝炎
肝纤维化
相关性
老年人
Serological indicators
Liver biopsy staging
Chronic liver disease
Liver fibrosis
Correlation
Elderly
