摘要
目的观察鹰嘴豆提取物(CAWE)对2型糖尿病大鼠糖、脂代谢的影响。方法采用高糖高脂饲料喂养4周后腹腔注射链脲佐菌素(STZ)45 mg/kg的方法,建立2型糖尿病大鼠模型。造模成功后灌胃低、中、高3个剂量组的鹰嘴豆提取物,观察空腹血糖(FPG)、血清胰岛素(FINS)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平的变化,计算肝指数、胰岛素敏感指数(ISI),观察肝脏、肾脏的组织病理学改变。结果与模型组相比,鹰嘴豆提取物能降低2型糖尿病大鼠的肝指数、血糖、TG、TC、LDL-C,增加ISI,能改善肝脏、肾脏病理损害。结论鹰嘴豆提取物具有降低血糖、调节血脂的作用。
Objective To observe the effect of Cicer arinum L.Water Extract（CAWE） on glucose and lipid metabolism of type 2 diabetes rats.Methods Animal model of type 2 diabetes was established by a high fat diet with intraperitoneal injection of STZ（low dose） into male SD rats and gave low-dose,middle-dose,high-dose of 2 compounds of CAWE.The level of Fasting plasma glucose（FPG）,Fasting insulin（FINS）,Total cholesterol（TC）,Triglyceride（TG）,High density lipoprotein cholesterol（HDL-C）,Low density lipoprotein cholesterol（LDL-C）,Insulin sensitivity index（ISI） and the pathological changes of the liver and kidney were evaluated.Results Compared with model group,the liver index,the level of FPG TG,TC,LDL-C in CAWE group declined,and ISI increased.It also can lighten the pathological lesion of the liver and kidney.Conclusion CAWE can adjust the blood glucose and lipid effectively.
出处
《新疆医科大学学报》
CAS
2011年第2期168-171,共4页
Journal of Xinjiang Medical University
关键词
糖尿病
高血脂
鹰嘴豆
大鼠
diabetes
hyperlipidemia
Cicer arinum L.（chickpea）
rat
