摘要
目的观察健脾理气方干预脾虚气滞型功能性消化不良的疗效和安全性。方法采用随机、阳性药物平行对照的方法,将60例符合纳入标准的功能性消化不良患者按随机数字表分为治疗组和对照组(各30例);治疗组予健脾理气方,对照组予吗丁啉,两组疗程均为4周。采用PAGI-SYM症状量表、中医证候量表及饮水负荷试验观察患者临床症状和胃感觉功能的变化情况,并观察不良事件。结果治疗组、对照组总有效率分别为86.7%和80.0%;组间临床疗效比较,差异有统计学意义(P<0.05)。治疗后两组的胃感知阈值、胃不适阈值均较治疗前升高(P<0.05);组间治疗后比较,差异有统计学意义(P<0.05)。治疗组各项中医证候积分治疗前后组内差异均有统计学意义(P<0.05),对照组胃脘胀满、嗳气吞酸、喜太息积分治疗前后组内差异有统计学意义(P<0.05);组间治疗后比较,胃脘胀满、胃脘疼痛、嗳气泛酸和饮食减少积分差异有统计学意义(P<0.05)。两组治疗期间均未发生不良事件。结论健脾理气方能显著缓解脾虚气滞型功能性消化不良患者的临床症状和胃感觉功能,且安全性较好。
Objective To observe the effects and safety of ＂Jianpi Liqi Decoction＂ in treating functional dyspepsia of spleen deficiency and qi stagnation.Methods Sixty FD cases of spleen deficiency and qi stagnation were randomly divided into treatment group and control group.Thirty cases in treatment group were administered with ＂Jianpi Liqi Decoction＂,thirty cases in control group were administered with Domperidone,three times before meal each day.Both groups were under treatment for four weeks.Before and after treatment,clinical symptoms and gastric sensory function changes were observed through the PAGI-SYM symptom rating scale,Chinese medical scale and water load test to assess the efficiency of Chinese medicine.Laboratory tests were taken before and after treatment to assess the safety of Chinese medicine.Results The total effective rates in treatment group and control group were 86.7% and 80% respectively（P0.05）.Gastric sensory thresholds of both groups were increased after treatment,with better improvement in treatment group than in control group（P0.05）.Compared with the control group,the treatment group had significant improvement in postprandial fullness,upper abdominal pain and acid reflux.No adverse events were found in both groups.Conclusions ＂Jianpi Liqi Decoction＂ can relieve clinical symptoms significantly and improve the gastric sensory function of FD of spleen deficiency and qi stagnation.
出处
《上海中医药杂志》
2011年第4期27-30,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市教委重点学科项目(J50305)
关键词
功能性消化不良
脾虚气滞
中医药疗法
健脾理气方
Functional dyspepsia
spleen deficiency and qi stagnation
Chinese medicine
＂Jianpi Liqi Decoction＂
