摘要
目的：研究缺血再灌流损伤脊髓血流量的变化及其与脊髓病理改变间的关系。方法：20只成年日本大耳白家兔随机分为对照组、缺血30min组、缺血60min组和缺血90min组，用氢清除法测定脊髓血流量（SCBF），尼氏染色观察受损脊髓病理变化。结果：完全缺血时SCBF为0ml·100g-1·min-1，再灌流过程中各组SCBF较缺血时有不同程度的恢复，但较伤前仍有不同程度的下降，并以缺血60min、90min组下降明显；脊髓病理改变以灰质受损最明显，病变严重程度为缺血90min组＞缺血60min组＞缺血30min组＞对照组。结论；缺血时间越长，再灌流后SCBF下降越明显，病理损害也越重。
Objective: To study the changes of spinal cord blood flow (SCBF) after ischemio-reperfusioninjury of the spinal cord. Then the relationship between SCBF changes and the pathological changes of thespinal cord was investigated. Methods: 20 adult rabbits were randomized into the control, 30 min ischemia,60 min ischemia and 90 min ischemia groups. SCBF was determined with hydrogen clearance method and thepathological changes of the spinal cord were observed after Nissl's staining. Results: During ischemic period,SCBF was 0 ml·100 g-1·min-1. In the course of reper fusion, SCBF recovered in different degrees in 3 ischemic groups but remained lower than the preischemic level. Ischemia was more marked in the 60 min ischemia and 90 min ischemia group. The gray matter of the cord was severely damaged and the damage wasthe most severe in the 90 min ischemia group, second severe in the 60 min ischemia group, third severe in the30 min ischemia group and least severe in the control. Conclusion: The longer the ischemia, the more markedthe decrease of SCBF after reperfusion and the more severe the pathological changes.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第7期475-478,共4页
Journal of Third Military Medical University
基金
全军"九五"攻关项目!96L035
关键词
脊髓损伤
脊髓血流量
病理学
家兔
再灌注损伤
spinal cord injury
ischemio-reperfusion
spinal cord blood flow
pathology
rabbit
