摘要
目的 探讨选择性溶栓药尿激酶原在显微外科的应用。方法 采用大白鼠提睾肌模型形成微小血栓 ,通过微循环活体观测、组织病理学观察及纤溶活性测定 ,探讨尿激酶原的溶栓效果及对全身纤溶活性的影响。结果 尿激酶原组溶栓率 92 3 % ,D 二聚体阳性率 83 3 % ,明显高于对照组 (P <0 0 5 ) ,FIB值、α2 PI活性变化与对照组相比差异无显著意义 (P >0 0 5 )。结论 尿激酶原能有效溶解微小血栓 ,对全身纤溶活性无明显影响 。
Objective\ To evaluate the valve of pro\|urokinase as a selective thrombolytic agent in microsurgery.Methods\ The levators muscle model in rats was used to investigate the effect of pro\|urokinase on dissolving ischemic thrombi and fibrinogenolytic activities in circulation by local infusion.The tissue microcirculation,pathologic appearance of rat lungs and muscles,and general fibrinogenolytic activities were observed.Results\ The thrombolytic rate of pro\|urokinase was 92\^3% ( P <0 05),the positive rate of D\|dime was 83\^3%(\%P\%<0\^05).No significant change of α 2 PI was observed on general fibrinogenolytic activites( P >0 05).Conclusions\ It is suggested that pro\|urokinase can be used to dissolve the thrombi in microcirculation of free tissue transplantation without affect general fibrinogenolytic activities.It is safe to use pro\|urokinase in free tissue transplantation.\;
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2000年第2期96-98,共3页
Chinese Journal of Plastic Surgery
