摘要
目的研究甲基鸟嘌呤－脱氧核糖核酸－甲基转移酶（ＭＧＭＴ）基因突变与急性白血病发病的关系。方法应用聚合酶链反应－单链构象多态性（ＰＣＲ－ＳＳＣＰ）技术对６２例急性白血病中ＭＧＭＴ基因进行了突变分析。结果ＭＧＭＴ基因突变在急性白血病中为１４．５％。结论急性白血病中存在ＭＧＭＴ基因突变，其在急性白血病的发生与发展中起到一定作用。
Objective To research the correlation between O6-methyl
guanine-DNA-methyl transferase(MGMT) gene mutations and acute leukemia. Method Sixty two
patients with acute leukemia were detected for mutations in MGMT gene using polymerase
chain reaction-single strand conformation polymorphism(PCR-SSCP). Results 14.5% patients
with acute leukemia contained MGMT gene mutations . Conclusion There are MGMT gene
mutations in acute leukemia and MGMT gene mutations may play an important role in the
pathogenesis of acute leukemia.
出处
《新乡医学院学报》
CAS
1999年第2期124-126,共3页
Journal of Xinxiang Medical University
关键词
急性
白血病
MGMT基因
PCR-SSCP
O6-methylguanine-DNA mythytransferase gene
acute leukemia
polymerase chain reaction-single strand conformation polymorphism
gene
mutation
