摘要
大蒜素片治疗组41例和消心痛治疗组26例冠心病心绞痛患者,比较其疗效,并观察治疗前后患者血浆GMP—140、TXB_2、NO及血液流变学等指标的变化。结果:大蒜素片对冠心病心绞痛的总有效率为85.4％,与消心痛基本相同,同时大蒜素片能明显降低患者血浆GMP—140、TXB_2的水平,升高患者血浆NO水平,并能显著改善患者的血液流变性。提示大蒜素片治疗冠心病心绞痛具有良好的疗效,其作用机理可能是抑制血小板活化,阻止血栓形成,扩张冠状动脉及外周血管,改善患者的血液流变性等。
Group of 41 cases and 26 cases of angina pectoris in CHD were treated with allicin tablet and Xiaoxintong respectively for comparison of their effect and changes in the indices of GMP-140, TXB2, 6-K-PGF1α, NO and hemorrheology were also observed. Results showed that the total effective rate of allicin tablet was 85. 4%, similar to Xiaoxintong. Allicin tablet can markedly lower the level of plasmal GMP - 140, TXB2. but increased the level of NO and substantially improve blood rheology, demonstrating that allicin tablet yield satisfactory effect on angina pectoris in CHD. The possible mechanism might lie on the activation of inhibition of platelets, prevention of thrombosis, dilatation of coronary arteries and peripheral vessels, improvement of hemorrheology.
出处
《中医杂志》
CSCD
北大核心
1999年第7期414-416,共3页
Journal of Traditional Chinese Medicine
关键词
心肌缺血
中医药疗法
大蒜辣素
血液流变学
: myocardial ischemia/TCM therapy allicin/ therapeutic application
