摘要
目的探讨血管紧张素转换酶（angiotensionconvertionenzyme，ACE）基因插入觖失（insertion／deletion，I／D）多态性与云南丽江纳西族脑血管病的相关性。方法纳入58例纳西族脑梗死患者、32例纳西族脑出血患者以及50例性别和年龄相匹配的纳西族健康对照者，采用聚合酶链反应一限制性片段长度多态性技术进行ACE基因多态性检测和双向测序。结果脑梗死组DD基因型（32．8％对16．O％，P=0．045）和D等位基因（54．3％对39．0％，P=0．025）频率均显著高于对照组，而脑出血组DD基因型和D等位基因频率与对照组无显著差异。不同脑梗死类型D等位基因携带频率不同，依次为脑栓塞〈脑血栓形成〈腔隙性梗死，腔隙性梗死患者DD基因型（40．0％对30．0％，P=0．481）和D等位基因频率（63．3％对51．2％，P=0．257）均高于脑血栓形成患者，但无显著差异。结论云南纳西族ACE基因DD型携带者具有脑梗死易感性。
Objective To investigate the correlation between the angiotensin-converting enzyme （ACE） gene insertion/deletion （I/D） polymorphism and cerebrovascular diseases in Naxi population in Lijiang, Yunnan province. Methods Fifty-eight Naxi patients with cerebral infarction, 32 Naxi patients with intracerebral hemorrhage, and 50 sex- and age-matched Naxi healthy controls were recruited. Polymerase chain reaction-restricted fragnents length polymorphism was used to detect the ACE gene polymorphism and perform bidirectional sequencing, Results The DD genotype and the D allele frequency in the cerebral infarction group were significantly higher than those in the healthy control group （32. 8% vs. 16. 0%, P = 0. 045 and 54. 3% vs. 39. 0%, P =0. 025）; while there were no sigaificant differences in the DD genotype and the D allele frequency between the intracerebral hemorrhage group and the control group. The different types of cerebral infarction carried different allele frequencies, they were in order of cerebral embolism 〈 cerebral thrombosis 〈 lacunar infarction. The DD genotype in patients with lacunar infarction （40. 0% vs. 30. 0%, P = 0. 481） and the D allele frequencies （63.3% vs.51.2%, P =0. 257） were all higher than those in patients with cerebral thrombosis, but there were no significant differences. Conclusions The ACE DD genotype carriers were susceptible to cerebral infarction in Naxi poulation in Ytman province.
出处
《国际脑血管病杂志》
北大核心
2011年第2期101-105,共5页
International Journal of Cerebrovascular Diseases
基金
云南省科学技术厅资助项目（2008CD010）
