摘要
本文研究了肾功能不良时抗心律失常药常咯啉的药效学。用二氯化汞诱导大鼠肾功能不良模型;用乌头碱诱发大鼠心律失常模型。实验大鼠分为4组。观察大鼠出现室早、室速、室颤时的乌头碱累积用量。实验结果,肾功能正常给药组与对照组间及肾功能不良给药组与对照组间有统计学差异。而肾功能不良对照组与肾功能正常对照组间及肾功能不良给药组与肾功能正常给药组间无统计学差异。实验结果说明肾功能不良对常咯啉药效无影响。
In studying the pharmacodynamics of antiarrhythmicdrug,Changrolin, rat modelswere used. Renal insufficiency rat models were induced by mercuric choride;arrhy-thmic rat models were induced by aconitine. The experimental rats were dividedinto four groups. The accumulative dose of aconitine was observed when the ventricu-lar premature systole, ventricular tachycardia and ventricular fibrillation appearedorderly. Comparing the treatment group with control group of normal renal function,and the treatment group with the control group of renal insaufficiency, all the observed data of treatment groups had statistical differences with their control groups.But when the two control groups or two treatment groups wore compared there wereno statistical differences. The result indicated that renal insufficiency had noinfluence on pharmacodynamics of Changrolin.
出处
《天津医药》
CAS
1990年第8期463-466,共4页
Tianjin Medical Journal
