摘要
本研究以9例原发性高血压伴肾功能不良的患者为对象,观察了口服心痛定后血浆血管紧张素Ⅱ水平的变化趋势以及在心痛定作用下,患者尿量、尿钠及内生肌酐清除率的变化。我们发现:本组病人服用心痛定后血浆血管紧张素Ⅱ(PATⅡ)水平下降,患者尿量(u.v)、尿钠(uNa)增加,内生肌酐清除率(C.Cr)升高。研究结果表示:口服心痛定对原发性高血压伴肾功能不良的病人,无交感神经兴奋及血管紧张素Ⅱ水平升高的作用,由于肾血流量的增加,患者肾功能亦得到改善。
Nine essential hypertension pati-ents with renal function disorder wereinvestigated The change of the plasmaAngiotesin-Ⅱ,patients'urine volume,urine sodium and creatinine clearancewere observed.We found,after takingnifedipine,the plasma Angiotensin Ⅱ(PAT-Ⅱ)level decreased,urine volume(U.V),urine sodium(U Na)andcreatinine clearance(C.C)Lincreased.The results suggest that there is noinfluence on the sympathetic nervoussystem and activity of rinin-angiote-nsin of the essential hypertension pait-ents with renal function disorder aftertaking Nife dipine since renal bloodflow were increased,the renal functionof teh patients were then improved.
