摘要
采用荧光光谱、差热扫描和核磁共振法研究了不同酸度和温度下β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)和磺丁醚-β-环糊精(SBE-β-CD)对氯诺昔康(LX)的包合特性。结果表明,3种环糊精与氯诺昔康均形成1∶1的包合物。以包合常数作为包合稳定性的量度,包合稳定性为SBE-β-CD>HP-β-CD>β-CD。
The inclusions of lornoxicam（LX） by β-cyclodextrin（β-CD）,hydroxypropyl-β-cyclodextrin（HP-β-CD）,and sulfobutyl ether-β-cyclodextrin（SBE-β-CD） were studied by fluorescence spectroscopy,differential scanning calorimetry（DSC） and NMR at different pH and temperature.The results showed that the 1∶ 1 inclusion compounds were formed between lornoxicam and CDs.Based on the formation constants,the interactions between lornoxicam and the three CDs follow an order of SBE-β-CDHP-β-CDβ-CD.
出处
《应用化学》
CAS
CSCD
北大核心
2011年第4期421-425,共5页
Chinese Journal of Applied Chemistry
基金
山西省科技厅自然科学基金(20051029)资助项目
