摘要
目的确定中长期失重防护措施研究的模拟失重动物模型。方法比较对照组鼠（ｎ＝１５）和尾吊鼠（ｎ＝１５）在实验３０ｄ后血循环、肌肉和骨骼系统的变化。结果尾吊可引起血液流变性和红细胞变形能力下降，肌肉萎缩，肌肉收缩功能下降，肌纤维的Ｉ型纤维向ＩＩ纤维转化，Ｌ３骨矿盐含量下降，股骨载荷功能降低和骨代谢变化。结论尾吊鼠可作为今后研究的模拟失重动物模型。
Objective To confirm the tail suspended rat model for the study of countermeasures against weightlessness. Method The changes of blood circulation, muscle and skeletal systems in control group rats (n=15) and 30 d tail suspended rats (n=15) were compared. Result Compared with the control group,the hemorrheology and erythrocyte deformability decreased significantly, muscle fiber atrophy ,muscle contraction function decreased, the type I muscle fibers transformed to the type II muscle fibers,bone mineral content of L3 and load capacity of femur declined, bone metabolism changed in the suspended rats. Conclusion The tail suspended rat is a suitable animal model for the study of countermeasures against weightlessness.
出处
《航天医学与医学工程》
CAS
CSCD
1999年第4期277-280,共4页
Space Medicine & Medical Engineering
关键词
模拟失重
血液循环
肌肉
骨骼
大鼠
simulated weightlessness
blood circulation
muscles
skeleton
