摘要
海洋新化合物 Ａ１９９８ ６．４，１９．２，５７．６ ｍｇ／ｋｇ剂量可明显降低四氧嘧啶及链脲霉素所致小鼠糖尿病模型的血糖含量，增加 ＡｌＣｌ３所致急性衰老大鼠血细胞膜 Ｎａ~＋，Ｋ~＋－ＡＴＰＮ活性．使ＡｌＣｌ３所致急性衰老大鼠细胞膜上活性受到损伤的 Ｎａ~＋，Ｋ~＋－ＡＴＰ酶活性恢复，增强胰岛细胞对葡萄糖反应的敏感性，从而起到降低血糖的作用。
The new compound A1998, di (3β－hydroxy-androst-5-en-17-one) adipate was isolated and modified from the marine creature of Asteras amurensis. At doses of 6. 4, 19. 2 and 57. 6 mg/kg (po), it can markedly reduce blood glucose level of diabetic mice induced by alloxan or streptozotocin; increase the activities of Na^+, K^+-ATPase on red cell membrane of acute senescent mice induced by AIC13, and increase the sensitivity of islet of Langerhans to reduce blood glucose.
出处
《中草药》
CAS
CSCD
北大核心
1999年第10期752-755,共4页
Chinese Traditional and Herbal Drugs
基金
国家"九.五"重点科技攻关项目!<海洋生物活性物质>(编号96-C02-04-01)
