摘要
以５，６－二氢－６－烷基（芳基）－２Ｈ－吡喃－２，４－二酮（１）、芳胺（２）和原甲酸三乙酯进行缩合反应，合成了２０ 个３－芳胺甲烯基－６－烷基（芳基）－５，６－二氢－２Ｈ－吡喃－２，４－二酮（３）． 由于分子内氢键的形成， 化合物３ 由一对构象异构体４ 和５ 组成． 生物活性初步测定结果表明，
Anilinomethylene 6 alkyl(aryl) 5,6 dihydro 2H pyran 2,4 diones(3) were prepared by the condensation reaction of 6 alkyl(aryl) 5,6 dihydro 2H pyran 2,4 diones(1), substituted anilines(2) and ethyl orthoformate. A pair of conformational isomers 4 and 5 exist in products 3 due to the formation of the intramolecular hydrogen bond. Compound 3 was tested in vitro against many fungi such as P. Zeae, C. Arachidicala, P. Piricola, A. Solani, B. Cinerae, S. Sclerotiorum, H. Oryzae, etc . The bioassay results show that they have some fungicidal activity.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第10期1559-1563,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学重点基金
关键词
二氢吡喃二酮
杀菌活性
衍生物
合成
杀菌剂
Condensation reaction
Intra molecular hydrogen bond
Conformational isomers
Fungicidal activity
