摘要
采用乙酰乙酸乙酯的双负离子与胡椒基甲基酮反应,合成了5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,然后与原甲酸三乙酯、芳胺进行缩合反应,得到了3 芳胺甲烯基 5,6 二氢 6 甲基 6 胡椒基 2H 吡喃 2,4 二酮,其结构经1HNMR和元素分析证实。生物活性初步测定表明,该类化合物具有一定的杀菌活性。
5, 6-Dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-dione, which was obtained by reacting dianion of acetoacetate with piperonyl methyl acetone, reacted with substituted anilines in the presence of ethyl orthoformate and 3-anilinomethylene-5, 6-dihydro-6-methyl-6-piperonyl-2H-pyran-2, 4-diones (2) were obtained.The Structures of compounds 2 were confirmed by 1~H NMR spectra and elemental analyses. Compound 2 was tested in vitro against many fungi such as P. Zeae, A. Solani, R. Solani, P. Piricola, C. Arachidicala. The bioassay results showed that they have some fungicidal activity.
出处
《精细化工中间体》
CAS
2004年第2期11-13,24,共4页
Fine Chemical Intermediates
基金
国家自然科学基金青年基金资助(20302003)。
关键词
双负离子
胡椒基甲基酮
杀菌
Dianion
Piperonyl methyl acetone
Fungicidal activity
