摘要
In this paper, by applying fluorescence quenching method and energy transfer technique, the interaction of serum albumin(BSA and HSA) with ketorolac and feprazone was investigated. The binding sites and binding constants were obtained. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and the main sort of binding force is static electricity gravitation.
In this paper, by applying fluorescence quenching method and energy transfer technique, the interaction of serum albumin(BSA and HSA) with ketorolac and feprazone was investigated. The binding sites and binding constants were obtained. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and the main sort of binding force is static electricity gravitation.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第10期1548-1550,共3页
Chemical Journal of Chinese Universities
基金
山东省自然科学基金
