摘要
目的分析抗核抗体(ANA)谱和ANA的临床检测结果及临床应用。方法选取120例患有自身免疫性疾病的患者作为疾病组;30例非自身免疫性疾病者为对照组。疾病组及对照组血清标本应用间接免疫荧光法、免疫印迹法检测ANA和ANA谱。结果系统性红斑狼疮(SLE)的发生与患者的性别,血清中抗nRNP/SM、抗Sm、抗RIB-P、抗dsDNA、抗核小体、抗组蛋白抗体呈正相关;混合性结缔组织病(MCTD)的发生与患者血清中抗nRNP/SM抗体呈正相关;进行性系统性硬化症(PSS)的发生与患者血清中抗着丝点抗体呈正相关;干燥综合征(SS)的发生与患者血清中抗SS-B(La)抗体呈正相关。结论 ANA谱的检测有助于自身免疫性疾病的诊断和筛查。
Objective To analyze the ANA profile,its clinical detction results and clinical application.Methods To select 120 cases of autoimmune disease as the disease group;30 cases of non-autoimmune diseases as the control.The serum samples in the two groups were detected by indirect immunofluorescence,Western blot for of ANA and the ANA spectrum.Results The occurrence of SLE was positively correlated with sex,serum anti-nRNP/SM,anti-Sm,anti-RIB-P,anti-dsDNS,anti-Nukleosomen,anti-Histone antibody.The occurrence of MCTD was positively correlated with anti-nRNP/SM antibody.The occurrence of PSS was positively correlated with anti-CENP B antibody.The occurrence of SS patients was positively correlated anti-SSB positive correlation.Conclusion ANA profile is helpful for the diagnosis and screening of autoimmune diseases.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第9期864-866,共3页
Chongqing medicine
