摘要
目的探讨血小板减少症患者抗核抗体(ANA)和抗核抗体谱(ANAs)的表达与其年龄和性别的关系。方法选取中国人民解放军第252医院肿瘤血液科2010年1月至2015年5月收治的123例初治的原发免疫性血小板减少症住院患者,根据患者年龄划分为三组,年龄1～20岁为A组(n=13例),其中男性4例,女性9例;年龄21～60岁为B组(n=87例),其中男性26例,女性61例,年龄≥61岁为C组(n=23例),其中男性10例,女性13例,各组再按照性别分为男性组及女性组,均经ANA与ANAs筛查,分析各组患者ANA及ANAs阳性情况。结果 (1) B组及C组患者ANA阳性率分别为35.6%及39.1%,均高于A组的23.1%,但差异均无统计学意义(P>0.05);A组患者的女性ANA阳性率为33.3%,高于本组男性的0,C组女性为46.2%,高于本组男性的30.0%,但差异均无统计学意义(P>0.05);B组女性ANA阳性率为46.0%,高于本组男性的11.5%,差异有统计学意义(P<0.05);三组所有患者女性ANA总阳性率为44.6%,明显高于三组所有男性的15.0%,差异有显著统计学意义(P<0.01)。(2) B组及C组患者ANAs阳性率分别为49.1%及43.4%,均高于A组的23.1%,但差异均无统计学意义(P>0.05);A组患者的男性ANAs阳性率为25.0%,高于本组女性的22.2%,差异无统计学意义(P>0.05);B组女性ANAs阳性率为59.0%,高于本组男性的26.9%,差异有统计学意义(P<0.05);C组女性ANAs阳性率为46.1%,高于本组男性的40.0%,差异无统计学意义(P>0.05);三组患者所有女性ANAs的总阳性率为53.0%,明显高于三组所有男性的22.5%,差异有显著统计学意义(P<0.01)。结论 ANA与ANAs在血小板减少症患者中的表达随着年龄增长有增高趋势,女性阳性率高于男性,对育龄期及更年期血小板减少患者尤其应进行ANA及ANAs筛查。
Objective To investigate the association of expressions of antinuclear antibody(ANA) and antinuclear antibody spectrum(ANAs) in patients with thrombocytopenia and their age and gender. Methods A total of 123 patients with newly diagnosed primary immune thrombocytopenia in Department of Hematology and Endocrinology, the 252 ndHospital of Chinese PLA from January 2010 to May 2015, were selected. They were divided into three groups by age: group A(1-20 years, 13 cases, including 4 males and 9 females, group B(21-60 years, 87 cases, including 26 males and 61 females), group C(≥61 years, 23 cases, including 10 males and 13 females). Each group was divided into male group and female subgroups by gender. ANA and ANAs of all patients were inspected, and the expression rates of ANA and ANAs were analyzed among different groups. Results(1) The ANA positive rates in group B and group C were35.6% and 39.1%, respectively, as compared with 23.1% in group A(P>0.05). The ANA positive rates of female patients in group A was 33.3%, as compared with 0 of male patients in group A(P>0.05). The ANA positive rates of female patients in group C was 46.2%, as compared with 30.0% of male patients in group C(P>0.05). The ANA positive rates of female patients in group B was 46.0%, as compared with 11.5% of male patients in group B(P<0.05). The ANA total positive rates of female patients in three groups was 44.6%, as compared with 15.0% of male patients in three groups(P<0.05).(2) The ANAs positive rates in group B and group C were 49.1% and 43.4%, respectively, as compared with 23.1% in group A(P>0.05). The ANAs positive rates of female patients in group A was 25.0%, as compared with 22.2% of male patients in group A(P>0.05). The ANAs positive rates of female patients in group B was 59.0%, as compared with 26.9% of male patients in group B(P<0.05). The ANAs positive rates of female patients in group C was46.1%, as compared with 40.0% of male patient in group C(P>0.05). The ANAs total positive rates of female patients in three groups were 53.0%, as compared with 22.5% of male patients in three groups(P<0.05). Conclusion Along with the growth of the age, expressions of ANA and ANAs in patients with thrombocytopenia was more and more higher. The incidence of thrombocytopenia in female patients was higher than that in male patients. In particular, ANA and ANAs should be screened for the patients of childbearing age and menopause with thrombocytopenia.
作者
秦伟
韩红满
左立辉
孙克
李四强
QIN Wei;HAN Hong-man;ZUO Li-hui;SUN Ke;LI Si-qiang(Department of Hematology and Endocrinology, the 252nd Hospital of Chinese PLA, Baoding 071000, Hebei, CHINA)
出处
《海南医学》
CAS
2019年第7期836-838,共3页
Hainan Medical Journal
基金
2017年河北省保定市科学技术研究与发展指导计划项目(编号:17ZF203)
