摘要
目的:探讨溃疡性结肠炎(UC)血清IL-23和IL-17的水平变化及其临床意义。方法:收集经临床明确诊断的UC患者54例,并选择同期健康体检者30例作为对照组。采用酶联免疫吸附法(ELISA)检测两组血清IL-23和IL-17的水平。结果:UC组患者血清IL-23和IL-17水平明显高于对照组,差异有显著统计学意义(t=18.76,21.48,P<0.01)。在轻度、中度、重度UC患者血清中,IL-23和IL-17的浓度水平均呈逐渐升高趋势,重度患者高于中度患者,中度患者高于轻度患者,三组间比较存在显著差异(P<0.05或0.01)。IL-23和IL-17在溃疡性结肠炎患者血清中的表达呈正相关(r=0.548,P<0.01)。结论:IL-23与IL-17的高表达可能参与了UC的慢性炎症形成过程;两者表达水平有密切相关性,IL-23可能通过诱导IL-17的产生而使后者在UC的发病中发挥作用。
AIM： To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance. METHODS： 40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected. The serum contents of IL-23 and IL-17 were determined bll ELISA. RESULTS： Serum contents of IL-23 and IL-17 in UC group were higher than those in control group significantly（ t = 18.76, 21.48, P 〈 0.01）. Serum contents of IL-23 and IL-17 increased with the clinical symptoms. Serum contents of IL-23 and IL-I7 in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly. Serum contents of IL-23 were positively correlated to IL-17 significantly （r=0.548, P〈0.01）. CONCLUSION： IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis. IL-23 may play a critical role in the development of UC through inducing production of IL-17.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2011年第2期203-204,共2页
Chinese Journal of Cellular and Molecular Immunology
