摘要
采用脑立体定向技术,移植培养的人胎肾上腺髓质组织至17例重症帕金森病患者脑内尾状核头部。移植术前后进行Webster 症状评分,头颅CT 检查,腰穿脑脊液DA 测定,血免疫球的蛋白、补体和T 淋巴细胞及其亚群检查,EEG、SEP 和VEP 检查,神经心理学测验和服药方面观察,随诊3～18个月。结果提示胎儿肾上腺髓质组织在脑内存活良好,临床效果比较满意,比目前其他移植治疗方法具有临床可行性和可靠性。
The fetal adrenal medullary tissue removed from the fetus donor aborted at theage of 24 weeks was cultured for one week.Appoximately 200～300mg tissue wereplaced at the head of bilateral caudate in 17 severe patients with PD.Follow-upstudy lasted 3 to 18 months.Clinical improvement was observed in all patients 3months after grafting.According to our clinical critical analysis.the clinical eficacywas sigificant downward and one of seventeen patients relapsed,and the responserate of transplantation was 92.86 percent in 6 months.The response rate of 6 to 12months was 87.5 percent.Immediately after operation the drug were withheld,ordecreased in dose.The low density areas in the head of caudate nucleus were foundby examination using CT within 1 to 10 days and disappeared one month afteroperation.This research has demonstrated that the human fetal adrenal medullarytissue can survive in the human brain and is associated with functon.The transplan-tation of the brain tissue is a useful method on the treatment of PD.
出处
《苏州医学院学报》
1990年第3期202-206,255-256+260,共5页
Acta Academiae Medicinae Suzhou
关键词
帕金森病
胎儿
肾上腺髓质
移植
fetal adrenal medullary tissue
tissue culture
transplantation
Parkinson's disease
