摘要
本文首次报告应用胎儿黑质组织尾状核内移植治疗3例帕金森氏病。供体眙儿胎龄分别为4个月、9周、9周。黑质移植物均为组织块形式。第1,2例采用立体定向技术在尾状核的2个靶点内植入组织、第2例还同时在移植对侧行丘脑腹外侧核损毁术。第3例改用开颅尾状核造腔移植,并在术后14周内应用免疫抑制剂CyclosporinA。目前病人已分别随访9~16月,其帕金森氏病的临床症状得到一定改善,但疗效尚未优于立体定向丘脑腹外侧核损毁术。同时,手术前后CSF中DA及代谢产物浓度没有明显变化。
Grafting of human fetal substantia nigra tissue pieces to the caudate nucleus in 3 patients with Parkinson's disease was first reported. Ages of the aborted fetus donor were 4 months (one ease) and 9 weeks (two cases) . Two targts were selected in the caudate nucleus and the transplantations were performed by means of the stereotaxic technique in case 1,2, Meanwhile, a contralateral stereotaxic thermoeoagulation was also carried out in the ventrolateral nucleus of the thalamus in case2. On the head of the right caudate nucleus of the third case, a cavity was made and tissue pieces was implanted with open microsurgery. Only in case 3, Cyclosporine A was given daily within the postoperative 14 weeks. Follow-up study (9-16 months)showed that all these cases demonstrated clinical improvement in some extent.But the real effect seemed not to surpass that performed stereotaxic lesion in the ventrolateral nucleus of the thalamus. No marked change were noted in CSF levels of DA and its metablities pre-and post-operatlvely. The authors also discuss the grafting effect,surgical m(?)nners, donor fetal age selection, grafted recipient treated by immunosuppression post operatieely and further clinical trials and so on.
出处
《中华神经外科杂志》
CSCD
北大核心
1989年第3期210-213,共4页
Chinese Journal of Neurosurgery
