摘要
目的探讨前列腺导管腺癌的临床病理和免疫组化特征。方法回顾性分析42例前列腺穿刺活检、经尿道前列腺切除和前列腺癌根治手术标本中的前列腺导管腺癌,所有病例均作34βE12、CK5/6、p63、AMACR、PSA和PAP免疫标记,并对照HE切片诊断。结果导管腺癌以周围型多见(39例,92.6%),有30例(21.4%)合并普通经典型腺癌。镜下以大腺泡为主,呈乳头状,筛孔状或管状结构,瘤细胞高柱状,核异型性明显。免疫组化表型类似经典型腺癌,但有23.8%的病例肿瘤性腺管周围有34βE12、CK5/6、p63标记阳性的基底细胞存在。结论导管腺癌与经典型腺癌相比,临床病理和免疫组化表现均有差异,病理诊断应注意与高级别上皮内瘤和转移性腺癌鉴别。
Purpose To study the clinicopathological and immunohistochemical features of prostate ductal adenocarcinoma.Methods 42 cases of prostate ductal adenocarcinoma from needle biopsy,transurethral prostatectomy and radical prostatectomy specimens were collected.All cases were immunostained with 34βE12,CK5/6,p63,AMACR,PSA and PAP antibodies.The Hematoxylin and eosin stained slides of each case were also reviewed.Results Most of the prostate ductal adenocarcinoma cases were peripheral type（39/42,92.6%）.30 cases were accompanied by conventional prostate adenocarcinoma.Histologically,tumors consist mostly of large acinar gland,presenting as papillary,cribriform and tubular structures.Tumor cells showed tall columnar shape and nuclear atypia.The immunohistochemical staining results of ductal adenocarcinoma were similar with that of the conventional adenocarcinoma,however,23.8% of the cases showed 34βE12,CK5/6,p63 positive staining of the basal cells.Conclusion There are both clinicopathological and immunohistochemcial differences between the ductal carcinoma and conventional prostate adenocarcinoma.Prostate ductal adenocarcinoma should be distinguished from metastatic adenocarcinoma and high grade prostate intraepithelial neoplasm（HGPIN）.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第6期704-706,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
前列腺肿瘤
导管腺癌
免疫组织化学
prostate neoplsms
ductal adenocarcinoma
immuhistochemistry
