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Toll样受体4与病毒感染的研究进展 被引量：5

Toll-like receptor 4 and viral infection
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摘要 Toll样受体4(TLR4)是固有免疫系统中能够识别病原相关分子模式的受体家族成员,可识别革兰氏阴性菌的脂多糖(LPS)而在细菌感染性疾病的发生中起重要作用。近年来越来越多的研究发现,TLR4还广泛参与病毒感染性疾病的发生和病毒的免疫逃逸,由于其信号转导通路的独特性和细胞定位的可变性,再次引起人们极大的研究兴趣。该文将介绍TLR4的生物学特性、信号转导通路及TLR4与病毒感染的最新研究进展。 Toll-like receptor 4（TLR4） is one of the members of TLRs,which can recognize pathogen-associated pattern molecules and activate innate immunity and acquired immunity.TLR4 plays a critical role in bacterial infections by recognizing lipopolysaccharide（LPS）.However,there are accumulating evidences indicating that TLR4 involves in viral infections and contributes to the immune escape of viruses.Moreover,the unique TLR4 signaling pathways and its cellular localization aroused our interest.Here we will review the most recent progress on TLR4,TLR4 signaling and viral infections.
作者 汤贤英 李晖
机构地区 武汉大学医学部病毒学研究所暨病毒学国家重点实验室 合肥医学院免疫学教研室
出处 《生命科学》 CSCD 北大核心 2011年第1期63-69,共7页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30500465 30810103052)
关键词 TLR4 信号转导通路 病毒感染 TLR4 TLR4 signaling pathway viral infection
分类号 R392 [医药卫生—免疫学] R378 [医药卫生—病原生物学]
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共引文献69

同被引文献54

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生命科学
2011年 第1期

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