期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TLR2抗病毒固有免疫作用研究现状

原文传递
导出
摘要 Toll样受体2(Toll like receptor 2,TLR2)是Toll样受体家族中重要的成员,在多种细胞表达,可识别多种配体使炎症因子释放,参与固有免疫和适应性免疫应答过程,在机体抗病毒感染中发挥重要作用。本文就近五年TLR2及其信号途径参与病毒感染性疾病发展过程作一综述。
作者 王颖君 运晨霞 冷静
机构地区 广西医科大学免疫学教研室 广西中医药大学微生物与免疫学教研室
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第5期417-420,共4页 Current Immunology
基金 国家自然科学基金资助项目(31160190) 广西自然科学基金重点项目(2011GXSFD018031)
关键词 TLR2 病毒感染 固有免疫
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献31

  • 1景志忠,何小兵,房永祥,陈国华,曾爽,贾怀杰.机体识别病毒核酸的几种分子模式及途径[J].畜牧兽医学报,2011,42(3):311-322. 被引量：13
  • 2景志忠,贾怀杰,周涛,何小兵.正痘病毒干扰宿主免疫应答的分子及其作用途径[J].畜牧兽医学报,2011,42(11):1503-1512. 被引量：3
  • 3Kawai T,Akira S.Toll-Iike receptor and their crosstalk with other innate receptors in infection and immunity [J].Immunity,2011,34:637-650.
  • 4O'Neill A,Bowie AG.The family of five:TIR-domain-con-taining adaptors in toll-like receptor signaling [J].Nat Rev Immunol,2007,7:353-364.
  • 5Lian JQ,Wang XQ,Zhang Y,et al.Correlation of circulating TLR2/4 expression with CD3+/4+/8+ T cells and Treg cells in HBV-related liver cirrhosis[J].Viral Immunol,2009,22:301-308.
  • 6Wang K,Liu H.Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure[J].Hum Immunol,2010,71:950-956.
  • 7Heiberg IL,Winther TN.Pattern recognition receptor responses in children with chronic hepatitis B virus infection [J].Clin ViroU 2012,54:229-234.
  • 8Zhang Y,Lian JQ.Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4 + CD25+ regulatory T cells in chronic hepatitis B virus infection[J].Virology,2010,397:34-42.
  • 9Chen J,Liang Z,Lu F,et al.Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine[J].Vaccine,2011,29:706-711.
  • 10Wu JF,Chen CH,Ni YH,et al.Toll-like receptor and hepatitis B virus clearance in chronic infected patients:a longterm prospective cohort study in Taiwan [J].Infect Dis,2012,206:662-668.

二级参考文献64

  • 1HABJAN M, ANDERSSON I, KLINGSTROM J, et al. Processing of genome 5' termini as a strategy of negative strand RNA viruses to avoid RIG-I-dependent interferon induction [J]. PLoS ONE, 2008, 3 (4) : e2032.
  • 2KATO H, TAKEUCHI O, MIKAMO-SATOH E, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5[J]. J Exp Med, 2008, 205 (7) :1601-1610.
  • 3SCHLEE M, ROTH A, HORNUNG V, et al. Recognition of 5 '-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus [J]. Immunity, 2009, 31(1):25-34.
  • 4CHIU Y H, MACMILLAN J B, CHEN Z J. RNA Polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway [J]. Cell, 2009, 138(3): 576-591.
  • 5KUMAR H, KAWAI T, KATO H, et al. Essential role of IPS-1 in innate immune responses against RNA viruses [J]. J Exp Med, 2006, 203(7) : 1795- 1803.
  • 6ISHIKAWA H, BARBER G N. STING is an endoplasmic reticulum adaptor that facilitates innate im mune signaling [J]. Nature, 2008, 455(7213): 674 678.
  • 7ZHONG B, YANG Y, LI S, et al. The adaptor protein MITA links virus-sensing receptors to IRF3 tran- scription factor activation [J]. Immunity, 2008, 29 (4): 538-550.
  • 8LOO YM, FORNEK J, CROCHET N, et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity [J]. J Virol, 2008, 82 (1): 335- 345.
  • 9WEBER F, WAGNER V, RASMUSSEN SB, et al. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses [J]. J Virol, 2006, 80(10): 5059-5064.
  • 10DIAO F, LI S, TIAN Y, et al. Negative regulation of MDASbut not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase [J]. Proc Natl Acad Sci USA, 2007, 104(28):11706-11711.

共引文献13

现代免疫学
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部