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Sox2在内耳发育中的作用 被引量：3

Effect of transcription factor Sox2 on the development of inner ear
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摘要 转录因子Sox2是Sox基因家族的成员之一,由于它在早期胚胎发生、神经分化和内耳发育等多种重要的发育事件中都起着关键的作用,从而引起了越来越广泛的关注。哺乳动物的内耳主要由6个形态上和功能上不同的感觉区组成,这些区域对声音和前庭信息的传导是必需的,在这些区域的发育过程中,Sox2基因是内耳细胞早期发育所必需的基因。该文就Sox2在内耳发育中的作用作一综述。 Transcription factor Sox2 is a member of Sox gene family.It gains general attention according to the key role in various important developmental events,such as early embryogenesis,neural differentiation,inner ear development and so on.The mammalian inner ear is composed of six functionally and morphologically distinct sensory regions,which are required for sound and vestibular information transduction.And Sox2 is required for the early development of inner ear cells in the develop process of the sensory regions.In this review,we focus on the Sox2 gene＇s role in inner ear development.
作者 陈道森 熊鹰
机构地区 第三军医大学学员旅
出处 《生命科学》 CSCD 北大核心 2011年第1期32-36,共5页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30770681) 重庆市自然科学基金项目(2008BB5020)
关键词 Sox2基因 内耳发育 毛细胞 支持细胞 Sox2 gene inner ear development hair cell supporting cell
分类号 R339.16 [医药卫生—人体生理学]
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参考文献18

  • 1Gubbay J, Collignon J, Koopman P, et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature, 1990, 346(6281): 245-50.
  • 2Kiernan AE, Pelling AL, Leung KK, et ai. Sox2 is required for sensory organ development in the mammalian inner ear. Nature, 2005, 434(7036): 1031-5.
  • 3Kelly MC, Chen P. Development of form and function in the mammalian cochlea. Curt Opin Neurobiol, 2009, 19(4): 395-401.
  • 4Puligilla C, Dabdoub A, Cheah KS, et al. Sox2 as a prosensory and proneural gene in the developing mouse cochlea. Dev Biol, 2008, 319(2): 535.
  • 5Hume CR, Bratt DL, Oesterle EC. Expression of LHX3 and SOX2 during mouse inner ear development. Gene Expr Patterns, 2007, 7(7): 798-807.
  • 6Kelley MW. Hair cell development: commitment through differentiation. Brain Res, 2006, 1091(1): 172-85.
  • 7Dabdoub A, Puligilla C, Jones JM, et al. Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci USA, 2008, 105(47): 18396-401.
  • 8Mak AC, Szeto IY, Fritzsch B, et al. Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development. Gene Expr Patterns, 2009, 9(6): 444-53.
  • 9Wood HB, Episkopou V. Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev, 1999, 86(1-2): 197-201.
  • 10Uchikawa M, Kamachi Y, Kondoh H. Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Mech Dev, 1999, 84(1-2): 103-20.

二级参考文献36

  • 1Hensch TK. Critical period regulation [J]. Annu Rev Neurosci, 2004, 27:549-579.
  • 2Zhang LI, Bao S, Merzenich MM. Persistent and specific influences of early acoustic environments on primary auditory cortex [J]. Nat Neurosci, 2001, 4(11): 1123-1130.
  • 3Zhang LI, Bao S, Merzenich MM. Disruption of primary auditory cortex by synchronous auditory inputs during a critical period [J]. Proc Natl Acad Sci USA, 2002,99(4): 2309-2314.
  • 4Chang EF, Merzenich MM. Environmental noise retards auditory cortical development [J]. Science, 2003, 300(5618): 498-502.
  • 5De Villers-Sidani E, Chang EF, Bao S, et al. Critical period window for spectral tuning defined in the primary auditory cortex (AI) in the rat [J]. J Neurosci, 2007, 27(1): 180-189.
  • 6Pantev C, Oostenveld R, Engelien A, et al. Increased auditory cortical representation in musicians [J]. Nature, 1998, 392(6678): 811-814.
  • 7Bakin JS, Weinberger NM. Classical conditioning induces CS-specific receptive field plasticity in the auditory cortex of the guinea pig [J]. Brain Res, 1990, 536(1-2): 271-286.
  • 8Edeline JM, Pham P, Weinberger NM. Rapid development of learninginduced receptive field plasticity inthe auditory cortex [J]. Behav Neurosci, 1993, 107(4): 539-551.
  • 9Rutkowski RG, Weinberger NM. Encoding of learned importance of sound by magnitude of representational area in primary auditory cortex [J]. Proc Natl Acad Sci USA, 2005, 102(38): 13664-13669.
  • 10Zhou X, Merzenich MM. Intensive training in adults refines A1 representations degraded in an early postnatal critical period [J].Proc Natl Acad Sci USA, 2007, 104(40): 15935-15940.

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生命科学
2011年 第1期

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