摘要
目的:探讨补中益气汤对阿霉素所致心肌损伤的保护作用及其作用机制。方法:50只SD大鼠随机分为5组:正常对照组,心衰模型组,补中益气汤低、高剂量组和卡托普利组。观察不同剂量补中益气汤干预对大鼠血流动力学指标及心肌组织中抗氧化能力的影响;病理学观察补中益气汤对心肌组织的保护作用;以流式细胞术测定补中益气汤对心肌组织凋亡的影响。结果:阿霉素导致心肌纤维肿胀、断裂,补中益气汤组心肌病变明显轻于模型组。补中益气汤显著升高心衰大鼠抗氧化能力,抑制阿霉素诱导的心肌细胞凋亡。结论:补中益气汤可显著减轻阿霉素对大鼠心肌的毒性作用,其作用机制与抗氧化和抑制凋亡有关。
Objective： To study the effects and mechanism of Buzhong Yiqi decoction on adriamycin-induced acute myocardial injury in rats. Method： 50 rats were randomly divided to five groups： control group, heart failure group, low dose Buzhong Yiqi decoction, high dose Buzhong Yiqi decoction and captopril group. Adfiamycin was injected into the latter four groups to built a model of heart failure. Then, the effects of different doses of Buzhong Yiqi decoction on hemodynamics, cardiac tissue histological changes, antioxidant capacity and apoptosis of the damaged hearts were studied. Result： Adriamycin led to myocardial fiber swelling and fracture, Buzhong Yiqi decoction could reduce myocardial lesions. Buzhong Yiqi decoction could also improve heart antioxidant capacity and inhibit adriamycin-induccd cardiomyocyte apoptosis. Conclusion： Buzhong Yiqi decoction could significantly ease adriamycin induced heart failure in rats, and the mechanism is related to anti-oxidation and inhibiting apoptosis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第4期508-510,共3页
China Journal of Chinese Materia Medica
基金
河北省科技厅项目(06276102D-27)
关键词
补中益气汤
阿霉素
心衰
保护作用
Buzhong Yiqi decoction
adriamycin
heart falure
protection
