摘要
目的验证富血小板血浆(PRP)复合无机牛骨(BIO-OSS)对兔胫骨种植体周骨缺损的修复作用。方法选择健康新西兰大白兔24只,采用自身对照方法。在动物的左右两侧胫骨体部上1/3距膝关节2 cm处各植入1枚种植体,并在种植体一侧建立骨缺损区,左侧为实验组,填充PRP与BIO-OSS复合物;右侧为对照组,填充生理盐水与BIO-OSS复合物。分别于术后2、4、6周处死动物各8只,行X线片检查,进行骨密度分析;行组织学染色检查,测量新生骨面积。结果术后2、4、6周骨密度分析显示实验组灰度值与对照组比较差异有统计学意义(P<0.05);术后2、4、6周实验组新生骨面积与对照组比较差异有统计学意义(P<0.05)。结论 PRP可以促进骨组织的再生与修复,PRP与BIO-OSS复合材料是良好的促进骨缺损修复的移植材料。
Objective To verity the reparation of the composite graft with PRP and deproteinizedbovinebonemineral（BIO-OSS） to the bone defect in dental implantation.Methods 24 healthy New Zealand white rabbits were selected.Defects and holes were made on the bilateral tibia in each side of the 1/3 and 2 centimeters from knee.Implantations were embedded in holes.The left side was experimental group and filled with BIO-OSS/PRP.The right was control group and filled with BIO-OSS/NS.The tibia healing was evaluated by X-ray film,histological analysis at 2,4,and 6 weeks postoperative.Specimens were measured by the computer in histological and new bone density analysis.Results Totally 24 rabbits were involved in the result analysis.A greater volume of new bone formation were observed in the graft sites that received PRP than the control at 2,4 and 6 weeks postoperatively（P0.05）.Conclusion PRP/BIO-OSS composite can remarkably facilitate the repair of rabbit tibia defects.And it is a more promising alternative to bone graft material.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第5期422-424,412,共3页
Chongqing medicine
基金
贵州省卫生厅资助项目(2007119)
关键词
富血小板血浆
骨缺损
种植体
platelet-rich plasma
bone defect
implants
