摘要
目的：探讨细胞遗传学分析方法研究慢性粒细胞白血病（CML）染色体异常特征及其临床意义。方法：对70例骨髓或外周血细胞采用短期培养法（24-48小时）制备染色体，以G显带进行核型分析，并观察接受治疗后患者的临床转归。结果：70例CML患者中，66例检出典型Ph染色体（94.29％），6例伴有染色体数目异常（8.57％），其中6例出现复杂易位（8.57％），4例出现附加染色体异常（5.71％），染色体数目异常预后较差。结论：CML患者进行染色体分析对于疾病的诊断、临床治疗、判断预后具有重要意义。
To investigate the features of chromosome abnormality by applying cytogenetics analysis and its clinical significance in chronic myelogenous leukemia （CML）.Methods：To prepare chromosome for bone marrow or peripheral blood cells by short term culture ,karyotyping was performed in 70 CML patients by G-banding.To observe the clinical outcomes of the patients after treatment.Resuits：Of 70 cases,66 cases were detected typical Ph chromosome （94.29%） and 6 cases had chromosome number abnormality （8.57%）.6 patients had variaht rearrangement （8.57%）.Extra chromosome changes were demonstrated in 4 cases （5.71%）.The patients of chromosome number abnormality had poor prognosis.Conclusion：Chromosome karyotype analysis is important in the diagnosis, treatment and judging prognosis of CML
出处
《现代医药卫生》
2011年第4期484-485,共2页
Journal of Modern Medicine & Health
关键词
慢性粒细胞白血病
染色体
核型异常
Chronic myeloid leukemia
Chromosome
Abnormal karyotype
