摘要
去甲丹皮酚或丹皮酚分别与非甾体抗炎药(NSAIDs)阿司匹林、布洛芬和双氯芬酸偶联,合成了5个新的去甲丹皮酚衍生物(3a～3c,4b)和丹皮酚衍生物(5b),其结构经1H NMR,IR和HR-MS表征。二甲苯致小鼠耳肿胀试验结果表明,3和5均有较强的抗炎活性,与阴性对照对CMC-Na相比,表现出显著性差异(P<0.01)。
Five novel resacetophenone derivatives（3a～3c,4b） and paeonol derivatives（5b） were synthesized by coupling NSAIDs with resacetophenone and paeonol,respectively.The structures were characterized by 1H NMR,IR and HR-MS.In xylene-induced mice ear swelling model,3 and 5 exhibited potent anti-inflammatory activities comparable with CMC-Na（P0.01）.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第1期28-31,共4页
Chinese Journal of Synthetic Chemistry
