摘要
目的探讨血浆中总超氧化物歧化酶（Ｔ－ＳＯＤ）、锰超氧化物歧化酶（Ｍｎ－ＳＯＤ）、铜锌超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ）活性和丙二醛（ＭＤＡ）含量变化在复发性口腔溃疡（ＲＯＵ）患者的诊断和治疗中的价值。方法实验采用比色法、硫代巴比妥酸法（改良ＴＢＡ法）测定了５２例ＲＯＵ患者治疗前后及５０例健康者血浆中Ｔ－ＳＯＤ、Ｍｎ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ活性和ＭＤＡ的含量。结果ＲＯＵ组与正常对照组相比较，血浆中Ｔ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ活性和ＭＤＡ含量有明显增高（Ｐ＜０．０５），而ＲＯＵ治疗后组与ＲＯＵ组血浆中Ｔ－ＳＯＤ、Ｍｎ－ＳＯＤ活性和ＭＤＡ含量有显著性差异（Ｐ＜０．０５），ＲＯＵ治疗后组与正常对照组相比较则没有显著性差异（Ｐ＞０．０５）。结论本实验结果为临床治疗ＲＯＵ选择适当剂量以及预后提供了理论依据。
Objective To study the diagnosis and treatment value of total superoxide dismutase(T-SOD), Mn-superoxide dismutase (Mn-SOD), CuZn-superoxide dismutase(Zn-SOD) activity and malondialdehyde(MDA) content in plasma for recurrent oral ulcer(ROU). Methods T-SOD, Mn-SOD, Zn-SOD activity and MDA content in plasma from 52 ROU patients before and after treatment and 50 healthy volunteers were measured with colorimetry and modified TBA colorimetry. Results T-SOD, Mn-SOD activity and MDA content decreased obviously after treatment ( P <0.05), but there was no significant difference ( P >0.05)between the cured group and the healthy volunteers. Conclusion The results has offered basis for dosage selection and prognosis assessment.
出处
《广东牙病防治》
1999年第3期168-169,共2页
Journal of Dental Prevention and Treatment
关键词
复发性
口腔溃疡
超氧化物歧化酶
丙二醛
recurrent oral ulcer(ROU)
superoxide dismutase(SOD)
malondialdehyde(MDA)
