摘要
目的:探讨胶体金技术对幽门螺杆菌(HP)分型诊断的价值。方法:应用胶体金技术检测86例消化性溃疡患者和22例无症状健康志愿者血清中的HP空泡毒素(VacA)、细胞毒素(CagA)和尿素酶(Ureas)等HP抗体。结果:慢性胃炎组、消化性溃疡组、胃癌组的HP型阳性率与对照组比较差异有统计学意义。慢性胃炎组HPⅡ型阳性率与对照组比较差异无统计学意义,随着病变恶性严重程度的增加,CagA/VacA的表达呈上升趋势,尤其是VacA的表达。结论:胶体金技术可应用于对HP感染分型诊断,为临床治疗及判断预后提供一定依据。
Objective：To investigate the applied value of colloidal gold assay to typing diagnosis of Helicobacter pylori（Hp） infection.Methods：Serum VacA,CagA and ureas antibodies of Hp in 86 patients with upper digestive tract diseases and 22 healthy volunteers without symptoms as control were detected by colloidal gold assay.Results：The Hp positive rate in the chronic gastritis group,peptic ulcer group and gastric cancer group had statistical difference compared with the control group.The HpⅡ positive rate in the chronic gastritis group was not statistically different from the control group＇s.And we found that with the lesion getting worse,the expression of VacA/CagA antibody showed rising trend,especially the expression of the VacA antibody in chronic gastritis.Conclusion：Colloidal gold assay can be used in detecting and typing Hp infection,which could provide some basis for clinical treatment and judging the prognosis.
出处
《现代医药卫生》
2011年第3期331-332,共2页
Journal of Modern Medicine & Health
关键词
胶体金技术
幽门螺杆菌
诊断
Colloidal gold assay
Helicobacter pylori
Diagnosis
