摘要
【目的】探讨慢性充血性心力衰竭（CHF）患者血清糖类抗原125（CAl25）及N末端B型钠尿肽原（NTproBNP）水平与患者心功能及其相关因素之间的关系。【方法】180例CHF患者通过超声测定左室内径及左室射血分数（LVEF），以电化学发光法（ECLIA）测定其血清CAl25和NT—proBNP水平，所有患者根据纽约心功能分级标准分为Ⅱ、Ⅲ、Ⅳ级组。另随机抽取40例有心血管疾病但无CHF的患者作为非CHF组。【结果】①CHF组血清CAl25及NTproBNP水平高于非CHF组，Ⅳ级心功能组水平明显高于Ⅲ级组，且Ⅲ级组明显高于Ⅱ级组；②血清CAl25及NT-proBNP水平均与LVEF呈负相关，而与导致CHF的原发病种类不相关。[结论]CHF患者血清CAl25及NT-proBNP水平升高，并且其水平与LVEF有关，而与导致CHF的原发病种类无关。
[Objective]To study the relation among the levels of serum carbohydrate antigen-125 （CA125） and plasma N terminal pro-natrinretic peptide（NT-proBNP） as well as the heart function in patients with con- gestive heart failure（CHF） . [Methods] One hundred and eighty patients with CHF were divided into three groups based on the standard of New York Heart Association Classification. Forty patients with cardiovascular disease but without CHF were served as control. The level of CA125 and BNP was measured by electrochem- iluminescence（ECIflA）. Left ventrlcular diameter and left ventricular ejection fraction （LVEF） was detected by echocardiography. [Results]Levels of CA125 and NT-proBNP in the patients with CHF were much higher than those without CHF, and were negatively associated with the LVEF independent of different kind of heart diseases. [Conclusion]Levels of CA125 and NT proBNP in patients with CHF are higher than those without CHF and they are related to the LVEF independent of the kinds of heart diseases.
出处
《医学临床研究》
CAS
2011年第1期35-36,39,共3页
Journal of Clinical Research
