摘要
目的探讨布-加综合征患者血清中CA125、CA19-9变化的临床意义。方法回顾分析2011年2月-2012年1月收治的188例布-加综合征患者血清CA125、CA19-9水平,分析布-加综合征不同亚型之间的差异,并与肝硬化患者和正常体检人群(对照组)血清CA125、CA19-9水平比较。试用ROC分析评价CA19-9、CA125对布-加综合征、肝硬化的诊断价值。结果布-加综合征组、肝硬化组血清CA125、CA19-9水平较高,与对照组比较差异均有统计学意义(P<0.05);布-加综合征组与肝硬化组血清CA19-9比较差异有统计学意义(P<0.01);但两组间血清CA125比较差异无统计学意义(P>0.05)。布-加综合征各分型间的CA125、CA19-9比较差异无统计学意义(P>0.05)。血清CA19-9用于诊断布-加综合征的最佳临界值为31.14 u/ml,灵敏度为64%,特异度为85.5%。结论血清CA125和CA19-9在评价布-加综合征患者肝损害程度、判断疾病发展有一定的临床意义。
Objective To discuss the clinical significance of the determination of serum CA19-9 and CA125 levels in patients with Budd-Chiari syndrome （BCS）. Methods During the period from Feb. 2011 to Jan. 2012, a total of 188 patients with BCS were admitted to authors＇ hospital. The recorded serum CA125 and CA19-9 levels were retrospectively analyzed. The differences in serum CA125 and CA19- 9 levels of different BCS types were analyzed. The serum CA125 and CA19-9 levels of BCS patients （BCS group） were compared with those of cirrhosis patients（cirrhosis group） as well as healthy subjects（control group）. By using ROC analysis the value of CA125 and CA19-9 levels in diagnosing BCS and cirrhosis was assessed. Results Statistically significant difference in CA125 and CA19-9 levels existed between BCS group and control group as well as between cirrhosis group and control group （P 〈 0.05）. The difference in CA19-9 levels between BCS group and cirrhosis group was also statistically significant （P 〈 0.01）, although the difference in CA125 levels between BCS group and cirrhosis group was not significant （P 〉 0.05）. The differences in CA125 and CA19-9 levels among different BCS types were not significant （P 〉 0.05）. The optimal marginal value of CA19-9 level in diagnosing BCS was 31.14U/ml, and the sensitivity and specificity were 64% and 85.5%, respectively. Conclusion The determination of CA125 and CA19- 9 levels has certain clinical value in assessing the severity of hepatic injury as well as in judging the progress of BCS. （J Intervent Radiol, 2012,21： 728-731）
出处
《介入放射学杂志》
CSCD
北大核心
2012年第9期728-730,共3页
Journal of Interventional Radiology
基金
国家自然科学基金资助项目(81141074)
