摘要
目的探讨右美托咪定用于腹腔镜胆囊切除术中的安全性和有效性。方法 ASAⅠ或Ⅱ级择期行腹腔镜胆囊切除术的患者32例,随机均分为右美托咪定组(D组)和生理盐水对照组(C组)。D组和C组于气管插管后手术开始前10min分别静脉泵注右美托咪定0.6μg/kg和生理盐水(泵注时间为10min)。两组均以吸入异氟醚维持麻醉。观察记录患者入室及切皮和拔管时的血压、心率以及术中维持麻醉时异氟醚的肺泡气浓度和拔除气管导管的时间。结果与入室时比较,切皮时和拔管时C组血压明显升高和心率明显增快(P<0.05),D组血压、心率无明显变化。D组术后烦躁的发生率显著低于C组(P<0.05)。结论右美托咪定可使腹腔镜胆囊切除术患者的血流动力学更稳定,术后苏醒迅速而完全。
Objective To investigate the safety and efficacy of dexmedetomidine in laparoscopic cholecystectomy.Methods Thirty-two patients ASA grade Ⅰ or Ⅱ,scheduled for selective 1aparoscopic cholecystectomy were randomly assigned to two groups：group D（intravenous dexmedetomidine 0.6 μg/kg）,group C（normal saline）.Each group had sixteen cases.Group D and group C respectively received dexmedetomidine and normal saline ten minutes before the operation by ways of intravenous infusion（the duration of infusion was ten minutes）.The maintainence of anesthesia used by isoflurane inhalation in both two groups.Patients＇ blood pressure,heart rate,alveolar air concentration of isoflurane and the time of extubation were recorded at the time of entering the operating room,skin incision and extubation.Results Compared with group D at the time of skin incision and extubation,the blood pressure and heart rate of group C were significantly increased in（P〈0.05）.In group C,the blood pressure and heart rate at the time of skin incision and extubation were significantly increased compared with basic（P〈0.05）.The incidence of postoperative restlessness was significantly lower（P〈0.05）.Conclusion Dexmedetomidine can make patients＇ hemodynamics more stable and the recovery more rapid and complete.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第1期47-48,共2页
Journal of Clinical Anesthesiology
